The Essential Tension by Sonya Bahar

Author:Sonya Bahar
Language: eng
Format: epub
Publisher: Springer Netherlands, Dordrecht

Alvarez-Curto et al. (2005) showed that genes for cAMP receptors already exist in group 1–3 species such as D. minutum, and are used in the formation of fruiting bodies, though not in the process of aggregation (which in D. minutum is driven by the acrasin folic acid). They suggested that the addition of new regulatory regions to existing cAMP signaling genes enabled cAMP to be exploited as a chemoattractant in the group 4 species. In a striking experiment, they expressed a cAR from D. minutum in a mutant strain of D. discoideum that lacks cARs with high affinity for cAMP. When the D. minutum protein was expressed, the mutant D. discoideum was able to aggregate virtually as effectively as the wild type.

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